Crippling HIV one mutation at a time

Crippling HIV one mutation at a time

Accumulating data suggest that not all human immunodeficiency virus (HIV)-1-specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that...

Combating HIV, One Tumor at a Time

The discovery by Luc Montagnier and Robert C. Gallo of a novel human retrovirus, and Gallo’s demonstration that this virus was the cause of AIDS, were the first major milestones in our efforts to understand, prevent, and treat the disease. surfaced. Though heroic measures were often utilized to try to treat these patients, they generally died within several months. It was not known how many peo...

Crippling of HIV at Multiple Stages with Recombinant Adeno-Associated Viral Mediated RNA Interference

One Loop at a Time

Classic techniques for proving termination require the identification of a measure mapping program states to the elements of a well founded domain and to show that this measure decreases with each iteration of a loop in the program. This is a global termination condition — there is a single measure which must be shown to decrease over all of the loops in the program. In this abstract we look at...

One step at a time

for these devices. But the macro layer of a network can be expanded to go a long way. In the near-term, the smartphone challenge is not about providing the capacity to cope with subscriber datausage, but is related to how the signaling system is configured. To build the networks that will cope with long-term predictions requires a new approach to network construction, heterogeneous networks – m...